In summer 2018, about 40 participants (independent living older adults aged 65 years and older) were included in a randomized controlled trial running in Switzerland. The participants were allocated either to the intervention group or the control group. The participants of the intervention group trained three times per week with the Active@Home exergame at their homes for a period of four months. The participants of the control group continued their normal daily life. Before and after the intervention, several physical and cognitive functions were assessed and the brain structure was measured using MRI technique. Preliminarily data analysis shows an improvement in some higher ordered cognitive functions (e.g. interference control) after exergame training compared to usual-care. Moreover, an improvement in heart rate variability was evident after the training period. Further data analysis including analysis of MRI data will be conducted in the next weeks.